BRIA is an interdisciplinary cybersecurity framework that integrates bioinformatics, immersive reality, and artificial intelligence. By combining these fields, BRIA aims to enhance threat detection, response strategies, and resilience against sophisticated cyberattacks. Bioinformatics contributes advanced data analysis and pattern recognition, immersive reality enables realistic simulation and training environments, and artificial intelligence powers adaptive defense mechanisms. This synergy allows organizations to anticipate, simulate, and counteract emerging threats more effectively. BRIA is particularly valuable for critical infrastructure, healthcare, and sectors where both digital and biological data security are paramount. Its holistic approach represents a shift towards more proactive and intelligent cybersecurity solutions.